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SAFREX – Improve your mood naturally
Purely herbal
Hormone-free
Appetite-suppressing
Saffron comes from the crocus species Crocus sativus L. and has a long medical tradition in the Orient. On the hunt for new herbal active ingredients, various research projects stepped up the focus on saffron and in numerous clinical studies, the mood-boosting, anxiety-relieving, neuroprotective, antioxidative and anti-inflammatory properties of saffron have been investigated and documented.
Cultivation, production and effect of saffron
The highly concentrated saffron extract is grown in Southern Europe and is produced under state-of-the-art conditions and in line with international quality standards.
SAFREX – The ingredient’s positive effect has been clinically proven
Highly concentrated saffron extract is a recognised and proven ingredient for treating typical side effects of the menopause. The positive effect and safety were documented impressively in several prospective, randomised, double-blind and placebo-controlled studies.
The mood-boosting effect of the SAFREX ingredient
Highly concentrated saffron extract has a mood-boosting effect, balances out nervousness and internal restlessness, relieves tension, alleviates anxiety and improves sleep, all while being easy to tolerate.
Like modern antidepressants, highly concentrated saffron extract acts as a reabsorption inhibitor of the psychically active neurotransmitters dopamine, serotonin and noradrenaline, which play a key role in depressive disorders. In a clinical comparative study, the highly concentrated saffron extract showed a similar effect to common prescriptive antidepressants, but without their side-effects.
Clinically proven effectiveness
Five clinical studies have proven the mood-boosting effect of the highly concentrated saffron extract SAFREX. The studies showed the saffron extract to be effective against 6 menopausal symptoms. The highly concentrated saffron extract is also proven to reduce sleeplessness by around 25% and improve sleep quality by around 20%. 4.
Sources: (1) Kell G, et al. A novel saffron extract improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complementary Therapies in Medicine. 2017 Aug;33:58-64. (2) Lopresti AL, et al. The Effects of a Saffron Extract on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study. J Menopausal Med. 2021 Aug;27(2):66-78.(3) Lopresti AL, et al. Efficacy of a standardised saffron extract as an add-on to antidepressant medication for the treatment of persistent depressive symptoms in adults: A randomised, double-blind, placebo-controlled study. J Psychopharmacol. 2019 Nov;33(11):1415-1427.(4) Lopresti AL, et al. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. J Clin Sleep Med. 2020 Jun 15;16(6):937-947.(5) Orio L, et al. Antianhedonic and Antidepressant Effects of a Standardized Saffron (Crocus Sativus L.) Extract. Molecules. 2020 Jul 15;25(14):3207.
Clinically proven mood-boosting effect: Three clinical studies impressively prove the mood-boosting effect of the highly concentrated saffron extract. In one study, symptoms such as depression, anxiety and insomnia (summarised as psychological score) improved by around 40% and signs of weakness and fatigue (somatic store) by more than 30% within 12 weeks2.
2) Lopresti AL, et al. The Effects of a Saffron Extract on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study. J Menopausal Med. 2021 Aug;27(2):66-78.
Clinically proven to improve sleep: A further clinical study was able to show that the highly concentrated saffron extract reduces sleeplessness by around 25% and improves sleep quality by around 20%4.
4) Lopresti AL, et al. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. J Clin Sleep Med. 2020 Jun 15;16(6):937-947.
No side effects, good tolerability: No side effects, good tolerability: Highly concentrated saffron extract is well tolerated, with no notable undesirable effects occurring in any of the clinical studies. There is no risk of daytime drowsiness or dependency and even other typical side effects of antidepressants are not known; no care needs to be paid to the subject of sunlight exposure either.
Of course, highly dosed saffron extract is hormone-free.
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